Limpopo's Department of Transport and Community Safety says that the R71 in Makgoebaskloof has been reopened for traffic.
This after a truck carrying gas cylinders crashed and the cylinders exploded on Tuesday night.
The vehicle went out of control and veered off the road.
The explosion also caused a runaway veld fire.
Transport spokesperson, Matome Taueatsoala has also appealed to drivers to obey traffic rules.