Three people died in the Inkanyezini area near Lion Park just outside Pietermaritzburg on Tuesday night when their car hit a barrier and plunged into a river.
Head of ALS Paramedics Garrith Jamieson said emergency teams responded to the crash site, which had been cordoned off by police.
Paramedics were told a single vehicle lost control and collided into the barrier and a water pump and ended up in the river.