Michael Carrick has the chance to make a fine first impression to his short-term stint as Manchester United manager by derailing local rivals Manchester Citys Premier League title challenge on Saturday.
City, meanwhile, have the chance to cut the gap on leaders Arsenal to three points at Old Trafford, while United need the points to boost their chances of Champions League football next season.
At the other end of the table, Tottenhams Thomas Frank and West Ham boss Nuno Espirito Santo are fighting to save their jobs as the sides clash in a London derby.