The Sharks have backed 18-year-old Zekhethelo Siyaya to make his debut against the Ospreys while Springbok captain Siya Kolisi, recovering from injury but included in the touring squad, is omitted from the matchday 23.
The Sharks take on the Welsh side in Swansea on Saturday kick-off 8.45pm, desperate to move up from 10th on the United Rugby Championship table but battling an injury crisis.
The Ospreys, meanwhile, are just three points behind the Durban union and will see this as an opportunity to claim a home win and climb towards a playoff spot.
