Nuno Espirito Santo's winless start to his West Ham reign has reached four games after Leeds cruised to a 2-1 victory at Elland Road on Friday.
Brenden Aaronson and Joe Rodon struck for Leeds in the first 15 minutes, with Mateus Fernandes's late reply coming too late to save the lacklustre Hammers.
Second-bottom West Ham are three points from safety after seven defeats in their first nine top-flight matches this season.
Nuno has taken one point from a possible 12, with a draw at Everton in his opening match followed by defeats against Arsenal, Brentford and Leeds.