Pickford will be replaced by Emile Burger with effect from 1 June, though Pickford will stay on for a month to ensure a seamless handover.
Burger had been serving as Tarsus chief financial and operating officer, and so he is intimately familiar with the Alviva-owned business. In this role, he spearheaded the diversification of the company's offering and expanded relationships with key partners.
He has a BCom in accounting, a BCom in financial management and an MBA.
"My focus will be on enhancing our capabilities, deepening and expanding our partner ecosystem, and advancing Tarsus's commitment to inclusive growth, ensuring we drive both innovation and economic impact," said Burger in a statement.