Liverpool slumped to a fourth consecutive defeat for the first time in 11 years as Manchester United won 2-1 on Sunday to end their near decade-long wait for victory at Anfield.
Harry Maguire's 84th minute header secured back-to-back Premier League wins for the first time in Ruben Amorim's tenure as United boss.
Twelve minutes from time, Cody Gakpo had cancelled out Bryan Mbeumo's opener after just 61 seconds.
Defeat leaves Liverpool four points adrift of Arsenal at the top of the table and Arne Slot still searching for answers in how to get the right blend after splashing out nearly 450 million on new players in the transfer market.
United close to within two points of their historic rivals and up to ninth in the table to ease the pressure on Amorim after his biggest win in nearly a year in charge.
"It means everything. They had had the better of us over the last few years and it's not been good for our club," said Maguire.
"We have not given our fans enough days like today, so it has been a long time coming, coming to this ground and picking up three points."
