George Ford will start at flyhalf for England against Australia in the first of their four autumn internationals on Saturday, with Fin Smith on the bench and no place for Marcus Smith.
In a Northampton-heavy backline, Alex Mitchell is scrumhalf with Fraser Dingwall and Tommy Freeman - who played all three British and Irish Lions tests against Australia on the wing - in the centres. The two started in midfield for England's win over Wales in this year's Six Nations.
Immanuel Feyi-Waboso and Tom Roebuck are on the wing, with Freddie Steward at fullback in the team named by coach Steve Borthwick on Tuesday - two days ahead of schedule.
There is no place in the squad for 19-year-old Saracens winger Noah Caluori, while in-form centres Henry Slade and Ollie Lawrence also miss out.