Eddie King Jr. doubled in the winning run in the seventh inning to lift Louisville to a 3-2 win over Miami on Sunday, advancing the Cardinals to their sixth College World Series.
King's clutch hit came after Jake Munroe's two-out single and a wild pitch.
Neither team was among the top 16 seeds, but the Cardinals 39-21 were the surprise winners of the Nashville Regional hosted by overall No. 1 seed Vanderbilt and Miami won Southern Mississippi's Hattiesburg Regional.
Louisville will face the Oregon State-Florida State winner in Omaha, Nebraska, later this week. Miami 34-26 was hoping for its 26th CWS appearance.
Miami took the lead on Max Galvin's two-run homer in the third. The Cardinals got those back in the fourth on an RBI double by Zion Rose and a fielder's choice.