Holthaus, who will leave after more than three decades with Intel, had held numerous senior leadership roles, including interim co-CEO following the ouster of former CEO Pat Gelsinger last year. She will remain a strategic adviser over the coming months.
Tan is seeking to flatten the companys leadership team, with most important chip groups reporting directly to him, while also slashing jobs to streamline operations.
Intel also said on Monday that Kevork Kechichian has joined as executive vice president and GM of the data centre group.