Three people died in a crash between a truck and car on the R23 between Heidelberg and Balfour on Saturday morning.
Arrive Alive said all services, including Lesedi fire and rescue, GPG Medical Services and Lesedi traffic assisted at the scene which occurred about 17km from Heidelberg, southeast of Johannesburg.
It said the highway was referred to as the road of death after numerous fatal accidents and urged motorists to take extreme care on the countrys roads ahead of the festive season.